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BioResource International Inc human complement regulatory protein cd46
Human Complement Regulatory Protein Cd46, supplied by BioResource International Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/human complement regulatory protein cd46/product/BioResource International Inc
Average 90 stars, based on 1 article reviews

human complement regulatory protein cd46 - by Bioz Stars, 2026-03

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Expression of Gal and NeuGc on heart, lung, kidney, liver, spleen, and lymph nodes of GTKO/hCD46 and GTKO/CD46/NeuGcKO pigs. All tissues from GTKO/hCD46 pigs were negative for Gal, but strongly positive for NeuGc, whereas tissues from two GTKO/hCD46/NeuGcKO pigs were negative for both antigens. (Magnification x200; nuclei, blue; Gal, green; NeuGc, red)

Journal: Xenotransplantation

Article Title: INITIAL IN VITRO STUDIES ON TISSUES AND CELLS FROM GTKO/CD46/NeuGcKO PIGS

doi: 10.1111/xen.12229

Figure Lengend Snippet: Expression of Gal and NeuGc on heart, lung, kidney, liver, spleen, and lymph nodes of GTKO/hCD46 and GTKO/CD46/NeuGcKO pigs. All tissues from GTKO/hCD46 pigs were negative for Gal, but strongly positive for NeuGc, whereas tissues from two GTKO/hCD46/NeuGcKO pigs were negative for both antigens. (Magnification x200; nuclei, blue; Gal, green; NeuGc, red)

Article Snippet: Adult pig (p) AECs were collected from wild-type (WT) pigs and from two different genetically-modified pigs provided by Revivicor, Blacksburg, VA - (i) GTKO pigs expressing the human complement-regulatory protein CD46 ( 32 ) (GTKO/hCD46 pigs) and (ii) GTKO/hCD46 pigs with additional knockout of NeuGc (GTKO/hCD46/NeuGcKO pigs).

Techniques: Expressing

Expression of Gal, NeuGc, and hCD46 on WT, GTKO/hCD46, and GTKO/hCD46/NeuGcKO pig cells and on human cells - (A) RBCs, (B) PBMCs. Human IgM (C) and IgG (D) binding to WT, GTKO/hCD46, and GTKO/hCD46/NeuGcKO pig and human RBCs. Human IgM (E) and IgG (F) binding to WT, GTKO/hCD46, and GTKO/hCD46/NeuGcKO pig PBMCs. (To prevent a false positive result from alloantibody binding, human PBMC were not tested for IgM/IgG binding.) (A, B) Gal was detected only on WT RBCs and PBMCs. NeuGc was detected on RBCs and PBMCs from WT and GTKO/hCD46 pigs. RBCs and PBMCs from GTKO/hCD46/NeuGcKO pigs and humans were negative for both Gal and NeuGc. The hCD46 molecule is not expressed on the surface of RBCs, but it is detected on the PBMCs from GTKO/hCD46 and GTKO/hCD46/NeuGcKO pigs and from humans. (C, D) There was a significant difference in human IgM and IgG binding between WT vs. GTKO/hCD46, GTKO/hCD46/NeuGcKO pRBCs, and human RBCs (*p<0.05, **p<0.01). There was also a significant difference in binding between GTKO/hCD46 and GTKO/hCD46/NeuGcKO pRBCs (‡p<0.05). There was no IgM/IgG binding to GTKO/CD46/NeuGcKO pig and human RBCs (a relative MFI<1 indicates no significant binding of IgM or IgG). (E,F) There were significant differences in human IgM and IgG binding between WT and GTKO/hCD46 pPBMCs (*p<0.05) and GTKO/hCD46 and GTKO/hCD46/NeuGcKO pPBMCs (‡p<0.05).

Journal: Xenotransplantation

Article Title: INITIAL IN VITRO STUDIES ON TISSUES AND CELLS FROM GTKO/CD46/NeuGcKO PIGS

doi: 10.1111/xen.12229

Figure Lengend Snippet: Expression of Gal, NeuGc, and hCD46 on WT, GTKO/hCD46, and GTKO/hCD46/NeuGcKO pig cells and on human cells - (A) RBCs, (B) PBMCs. Human IgM (C) and IgG (D) binding to WT, GTKO/hCD46, and GTKO/hCD46/NeuGcKO pig and human RBCs. Human IgM (E) and IgG (F) binding to WT, GTKO/hCD46, and GTKO/hCD46/NeuGcKO pig PBMCs. (To prevent a false positive result from alloantibody binding, human PBMC were not tested for IgM/IgG binding.) (A, B) Gal was detected only on WT RBCs and PBMCs. NeuGc was detected on RBCs and PBMCs from WT and GTKO/hCD46 pigs. RBCs and PBMCs from GTKO/hCD46/NeuGcKO pigs and humans were negative for both Gal and NeuGc. The hCD46 molecule is not expressed on the surface of RBCs, but it is detected on the PBMCs from GTKO/hCD46 and GTKO/hCD46/NeuGcKO pigs and from humans. (C, D) There was a significant difference in human IgM and IgG binding between WT vs. GTKO/hCD46, GTKO/hCD46/NeuGcKO pRBCs, and human RBCs (*p<0.05, **p<0.01). There was also a significant difference in binding between GTKO/hCD46 and GTKO/hCD46/NeuGcKO pRBCs (‡p<0.05). There was no IgM/IgG binding to GTKO/CD46/NeuGcKO pig and human RBCs (a relative MFI<1 indicates no significant binding of IgM or IgG). (E,F) There were significant differences in human IgM and IgG binding between WT and GTKO/hCD46 pPBMCs (*p<0.05) and GTKO/hCD46 and GTKO/hCD46/NeuGcKO pPBMCs (‡p<0.05).

Techniques: Expressing, Binding Assay

(A) Expression of Gal, NeuGc, and hCD46 on GTKO/hCD46, and two GTKO/hCD46/NeuGcKO pigs islet cells. GTKO/hCD46 pig islets were negative for Gal, but positive for NeuGc and hCD46. GTKO/hCD46/NeuGcKO pig islets were negative for both Gal and NeuGc expression, and positive for hCD46. (B) Human IgM and IgG binding to GTKO/hCD46, and GTKO/hCD46/NeuGcKO pig islet cells. There was no statistical significance in IgM and IgG binding to islets between the two groups.

Journal: Xenotransplantation

Article Title: INITIAL IN VITRO STUDIES ON TISSUES AND CELLS FROM GTKO/CD46/NeuGcKO PIGS

doi: 10.1111/xen.12229

Figure Lengend Snippet: (A) Expression of Gal, NeuGc, and hCD46 on GTKO/hCD46, and two GTKO/hCD46/NeuGcKO pigs islet cells. GTKO/hCD46 pig islets were negative for Gal, but positive for NeuGc and hCD46. GTKO/hCD46/NeuGcKO pig islets were negative for both Gal and NeuGc expression, and positive for hCD46. (B) Human IgM and IgG binding to GTKO/hCD46, and GTKO/hCD46/NeuGcKO pig islet cells. There was no statistical significance in IgM and IgG binding to islets between the two groups.

Techniques: Expressing, Binding Assay

Expression of Gal and NeuGc on pig and human aortas (A) and corneas (B) by immunofluorescence, and on cultured AECs (C) and CECs (D) by flow cytometry. (A, B) Gal was detected on the endothelium of WT pig aortas (red arrows) and epithelium and stroma of WT pig corneas. NeuGc was strongly detected on aortas and corneas from WT and GTKO/hCD46 pigs (Magnification x200; nuclei, blue; Gal, green; NeuGc, red). (C, D) Gal was detected on AECs and CECs of WT pigs, whereas NeuGc was detected on AECs from WT and GTKO/hCD46 pigs. Cells from GTKO/hCD46/NeuGcKO pigs and humans were negative for both Gal and NeuGc antigens.

Journal: Xenotransplantation

Article Title: INITIAL IN VITRO STUDIES ON TISSUES AND CELLS FROM GTKO/CD46/NeuGcKO PIGS

doi: 10.1111/xen.12229

Figure Lengend Snippet: Expression of Gal and NeuGc on pig and human aortas (A) and corneas (B) by immunofluorescence, and on cultured AECs (C) and CECs (D) by flow cytometry. (A, B) Gal was detected on the endothelium of WT pig aortas (red arrows) and epithelium and stroma of WT pig corneas. NeuGc was strongly detected on aortas and corneas from WT and GTKO/hCD46 pigs (Magnification x200; nuclei, blue; Gal, green; NeuGc, red). (C, D) Gal was detected on AECs and CECs of WT pigs, whereas NeuGc was detected on AECs from WT and GTKO/hCD46 pigs. Cells from GTKO/hCD46/NeuGcKO pigs and humans were negative for both Gal and NeuGc antigens.

Techniques: Expressing, Immunofluorescence, Cell Culture, Flow Cytometry

Human IgM and IgG antibody binding to pig and human AECs (A, B) and CECs (C, D) by flow cytometry. (A, B) Human IgM and IgG binding to GTKO/hCD46 pAECs was significantly decreased compared to WT pAECs (*p<0.05), and was further decreased to GTKO/hCD46/NeuGcKO pAECs (*p<0.05). Also, there was a significant difference in IgM and IgG binding to GTKO/hCD46 and GTKO/hCD46/NeuGcKO pAECs (‡p<0.05). There was significantly greater IgM binding to GTKO/hCD46/NeuGcKO pAECs than human AECs (‡p<0.05), but there was no statistical significance in the extent of IgG binding between them. (C, D) Human IgM and IgG binding to WT pCECs was significantly greater than to CECs from the other pigs (*p<0.05), but there was no significant difference in binding between these other pigs.

Journal: Xenotransplantation

Article Title: INITIAL IN VITRO STUDIES ON TISSUES AND CELLS FROM GTKO/CD46/NeuGcKO PIGS

doi: 10.1111/xen.12229

Figure Lengend Snippet: Human IgM and IgG antibody binding to pig and human AECs (A, B) and CECs (C, D) by flow cytometry. (A, B) Human IgM and IgG binding to GTKO/hCD46 pAECs was significantly decreased compared to WT pAECs (*p<0.05), and was further decreased to GTKO/hCD46/NeuGcKO pAECs (*p<0.05). Also, there was a significant difference in IgM and IgG binding to GTKO/hCD46 and GTKO/hCD46/NeuGcKO pAECs (‡p<0.05). There was significantly greater IgM binding to GTKO/hCD46/NeuGcKO pAECs than human AECs (‡p<0.05), but there was no statistical significance in the extent of IgG binding between them. (C, D) Human IgM and IgG binding to WT pCECs was significantly greater than to CECs from the other pigs (*p<0.05), but there was no significant difference in binding between these other pigs.

Techniques: Binding Assay, Flow Cytometry

Human PBMC proliferative response to GTKO/hCD46 and GTKO/hCD46/NeuGcKO pAECs and islet cells. CFSE-labeled human PBMC were cocultured with either GTKO/hCD46 or GTKO/hCD46/NeuGcKO pAECs at 1:10 ratio for 5 days. Similarly, human PBMC were cocultured with islet cells at 1:1 ratio. The proliferative response to pAECs and islet cells was weak. The response to GTKO/hCD46/NeuGcKO AECs was slightly weaker than to GTKO/hCD46 AECs, as was the response to the respective isolated islet cells. (Representative data from experiments using PBMCs from two different humans)

Journal: Xenotransplantation

Article Title: INITIAL IN VITRO STUDIES ON TISSUES AND CELLS FROM GTKO/CD46/NeuGcKO PIGS

doi: 10.1111/xen.12229

Figure Lengend Snippet: Human PBMC proliferative response to GTKO/hCD46 and GTKO/hCD46/NeuGcKO pAECs and islet cells. CFSE-labeled human PBMC were cocultured with either GTKO/hCD46 or GTKO/hCD46/NeuGcKO pAECs at 1:10 ratio for 5 days. Similarly, human PBMC were cocultured with islet cells at 1:1 ratio. The proliferative response to pAECs and islet cells was weak. The response to GTKO/hCD46/NeuGcKO AECs was slightly weaker than to GTKO/hCD46 AECs, as was the response to the respective isolated islet cells. (Representative data from experiments using PBMCs from two different humans)

Techniques: Labeling, Isolation

The effect of genetic modification on pAEC-induced human platelet aggregation. When human platelet aggregation associated with WT pAEC (54%) was compared with that to hAEC (4%), a significant difference was observed (***p<0.001). GTKO/hCD46 (42%) and GTKO/hCD46/NeuGcKO (39%) pAEC significantly reduced the aggregation compared to WT pAEC (*p<0.05), but aggregation remained significantly greater than to hAEC (**p<0.01). There was no significant difference in platelet aggregation between GTKO/hCD46 and GTKO/hCD46/NeuGcKO.

Journal: Xenotransplantation

Article Title: INITIAL IN VITRO STUDIES ON TISSUES AND CELLS FROM GTKO/CD46/NeuGcKO PIGS

doi: 10.1111/xen.12229

Figure Lengend Snippet: The effect of genetic modification on pAEC-induced human platelet aggregation. When human platelet aggregation associated with WT pAEC (54%) was compared with that to hAEC (4%), a significant difference was observed (***p<0.001). GTKO/hCD46 (42%) and GTKO/hCD46/NeuGcKO (39%) pAEC significantly reduced the aggregation compared to WT pAEC (*p<0.05), but aggregation remained significantly greater than to hAEC (**p<0.01). There was no significant difference in platelet aggregation between GTKO/hCD46 and GTKO/hCD46/NeuGcKO.

Techniques: Modification